Growth Inhibition of Plasmodium falciparum and Micobacterium tuberculosis Using Cortex Extract and Partition of Lannea coromandelica [Houtt.] Merr.)

  • Nursalam Hamzah Jurusan Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Alauddin
  • Nurhidayah Wahid Jurusan Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Alauddin
  • Muh Ihsan Jurusan Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Alauddin
  • Nur Syamsi Dhuha Jurusan Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Alauddin
  • Karnila Amir Tahir Jurusan Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Alauddin
  • Alifia Putri Febrianti Jurusan Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Alauddin
  • Isriany Ismail Jurusan Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Alauddin

Abstract

Malaria and tuberculosis are two diseases with high prevalence in Indonesia. The treatment has a problem because some types of plasmodium and mycobacterium resistance with antituberculosis and antimalarials which are used today. To solve this problem, exploration to create a new drug must be done. Kayu jawa (Lannea coromandelica [Houtt.] Merr.) is one of the plants commonly used as a traditional medicine for curing malaria and tuberculosis. This research aimed to explore the antimalaria dan antituberculosis of L. Coromandelica. The procedure begins with the extraction of stem bark with methanol, then partitioned by solid-liquid extraction to found soluble and insoluble hexane partitions. Both extract and partitions were tested for anti-plasmodium activity by Desjardins method and antituberculosis by MODS method. The result showed that all samples can inhibit Mycobacterium tuberculosis growth and also Plasmodium falciparum. In conclusion, L. Coromandelica has a potential to developed as antimalaria and antituberculosis drug.

Published
Feb 19, 2018
How to Cite
HAMZAH, Nursalam et al. Growth Inhibition of Plasmodium falciparum and Micobacterium tuberculosis Using Cortex Extract and Partition of Lannea coromandelica [Houtt.] Merr.). Journal of Pharmaceutical and Medicinal Sciences, [S.l.], v. 2, n. 2, feb. 2018. ISSN 2580-328X. Available at: <http://jpms-stifa.com/index.php/jpms/article/view/54>. Date accessed: 14 dec. 2018.
Section
Articles